A Novel pH-Sensitive Chiral Amphiphile: Synthesis, Aggregation, and Interaction with â-Cyclodextrin
نویسندگان
چکیده
A novel pH-sensitive chiral amphiphile, N-(4-decyloxy-2hydroxybenzylidene)-L-leucine, was synthesized. Two kinds of vesicles were found at different pH ranges, 6.5-8.0 and 11.5-12.5, and a helical structure was observed at pH ) 11.0. This unique behavior can be attributed to the formation of a dimeric structure. The interaction between this amphiphile and â-cyclodextrin was investigated by fluorescence emission spectra, 1H NMR, and molecular modeling.
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